Etudes cliniques en cours

Découvrez ici la liste des différentes études cliniques en cours classées par centre.

CHU Liège

  • Neodjuvant/adjuvant
    NSCLC resectable Iib/IIIa
    MK3475-671
    Platinum doublet chemotherapy ± pembrolizumab
  • 1-2LM
    NSCLC Squameux/non-squameux
    CANFOUR
    • Cisplatine/gemcytabine + CAN 04
    • CAN04 seul
  • NSCLC
    Slots variables
    GCT1021 -01
    Humax-AXL-ADC
  • NSCLC
    Slots variables
    CNIR
    PDR001 + NIR178
  • adjuvant
    NSCLC RO
    GO39733
    Atezolizumab + vaccin personnalisé
  • NSCLC
    Slots variables
    Pivot 02
    Nektar-IL2 + nivo Q3W

CHU Mont-Godinne

Etudes sponsorisées interventionnelles en cours:

  • PEARLS: A randomized, phase 3 trial with anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) versus placebo for patients with early stage NSCLC after resection and completion of standard adjuvant therapy.
  • Intr@pid: A Phase II, Multicenter, Randomized, Open-Label, Controlled Study of M7824 versus Pembrolizumab as a First-line Treatment in Patients with PD-L1 Expressing Advanced Nonsmall Cell Lung Cancer.

Etudes sponsorisées non interventionnelles en cours:

  • BEPACT Lung: Impact of Patient Characteristics on pneumo-oncologists NSCLC systemic treatment decision in Belgium: A cross-sectional study.

Etudes académiques non interventionnelles en cours:

  • ELCWP: Cardiovascular morbidities and lung cancer treatment: a prospective registry.

Cliniques Universitaires Saint-Luc

Etudes Onco en cours
1st line
AcronymeStudiesCancerPI
BO29554 study (B-FAST)A phase II/III multicentre study evaluating the efficacy and safety of multiple targeted therapies as treatments for patients with advanced or metastatic non-small cell lung cancer (NSCLC) harbouring actionable somatic mutations detected in blood (B-Fast: blood-first assay screening trial)NSCLC (ROS+) A venir: BRAF V600+P.C
ADRIATIC (D933QC00001)Phase III, randomised, double-blind, placebo-controlled, multi-centre study assessing the efficacy and safety of durvalumab or durvalumab and tremelimumab in patients with LD-SCLC who have not progressed following definitive, platinum-based, concurrent chemoradiation therapy (CRT)SCLC limités post-chimioradioT.P
ANAM 17-21A phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study to evaluate the efficacy and safety of Anamorelin HCl for the treatment of malignancy associated weight loss and anorexia in adult patients with advanced NSCLCNSCLC cachexiaT.P
Zenith20 (Spectrum) (SPI-POZ-202)Phase 2 Study of Poziotinib in Patients with Non-Small Cell Lung Cancer (NSCLC), Locally Advanced or Metastatic, with EGFR or HER2 Exon 20 Insertion Mutation (ZENITH20) (SPI-POZ-202)NSCLC IV EGFR ou HER2 exon 20 inser/mutT.P
CA209-73LA Phase 3, Randomized, Open-Label Study to Compare Nivolumab Plus Concurrent Chemoradiotherapy (CCRT) followed by Nivolumab Plus Ipilimumab or Nivolumab plus CCRT Followed by Nivolumab vs CCRT followed by Durvalumab in Previously Untreated, Unresectable Locally Advanced Non-Small Cell Lung Cancer (LA NSCLC)NSCLC IIIA/B/CTP
2nd line
ImmunoSABRPhase II study examining the activity of L19-IL2 immunotherapy and stereotactic ablative radiotherapy in metastatic non-small cell lung cancer NSCLC IVX.G
AMG510 (20190009)A Phase 3 Multicenter, Randomized, Open
Label, Active-controlled, Study of AMG 510
Versus Docetaxel for the Treatment of Previously
Treated Locally Advanced and Unresectable or
Metastatic NSCLC Subjects With Mutated KRAS
p.G12C
NSCLC KRAS p.G12CThP
3rd line
ImmunoSABRPhase II study examining the activity of L19-IL2 immunotherapy and stereotactic ablative radiotherapy in metastatic non-small cell lung cancer NSCLC IVX.G
Autres
AcronymeStudiesCancerPI
EORTC: E2-Radiate 1811E²-RADIatE:
EORTC-ESTRO RADiotherapy InfrAstrucTure for Europe
Tous cancers oligométa traités par RthXG
PACIFIC R D4194R00005First real-world data on unresectable stage III NSCLC patients treated with durvalumab after chemoradiotherapyNSCLC stage III with durvalumab post chimioradioT.P
Immuno PoumonEtude prospective des facteurs pronostics et prédictifs de l'immunothérapie dans le cancer du poumonNSCLC FAb
SPECTAScreening Cancer Patients for Efficient Clinical Trial AccessNSCLC IV naïfs/ thymomes, mésothéliome IV naïfsT.P

GHdC

CategorySub-categoryNameEudractTitleMoleculesPhaseEtudeStatus
Lung and ThoraxNSCLC01151Cardiovascular morbidities and lung cancer treatment: a prospective registryObservationnelleOpen
Lung and ThoraxNSCLCPDC-Lung-1012018-002382-19An open-label, dose escalation phase I/II study assessing the safety and immunogenicity of PDC*lung, therapeutic cancer vaccine, as single agent or in combination with a checkpoint inhibitor, in patients with Non-Small Cell Lung Cancer (NSCLC) PDC*lung01Phase 1aOpen
Lung and ThoraxNSCLCANAM-17-212018-002927-40A phase 3, randomized, double-blind, placebo-controlled, multicenter study to evaluate the efficacy and safety of anamorelin HCl for the treatment of malignancy associated
weight loss and anorexia in adult patients with advanced non-small cell lung cancer (NSCLC)
Anamorelin HCLPhase 3Open
Lung and ThoraxNSCLCSAPPHIRE2019-001043-41 A randomized phase 3 study of Sitravatinib in combination with Nivolumab versus Docetaxel in patients with advanced non-squamous non-small cell lung cancer with disease progression on or after platinum-based chemotherapy and checkpoint inhibitor therapy.SitravatinibPhase 3Open
Lung and ThoraxNSCLCPACIFIC-42018-002572-41A Phase III, Randomized, Placebo-controlled, Double-blind, Multi-center, International Study of Durvalumab Following Stereotactic Body Radiation Therapy (SBRT) for the Treatment of Patients With Unresected Stage I/II, Lymph-node Negative Non-small Cell Lung Cancer (PACIFIC-4/RTOG-3515)DurvalumabPhase 3Open
Lung and ThoraxNSCLCEXCLAIM-22019-001845-42Phase III clinical trial evaluating TAK-788 versus platinum-based chemotherapy (pemetrexed/cisplatin or pemetrexed/carboplatin) as first-line treatment for patients with non-small cell lung cancer with EGFR exon 20 insertion mutations.
TAK-788 Phase 3Open
Lung and ThoraxNSCLCSkyscraper 032019-0044773-29A phase 3, open-label, randomized study of Atezolizumab and Tiragolumab compared with Durvalumab in patients with locally advanced, unresectable stage 3 non-small cell lung cancer who have not progressed after concurrent platinum-based chemoradiation.TiragolumabPhase 3Open
Lung and ThoraxNSCLCMARIPOSA2020-000743-31A Phase 3, Randomized Study of Amivantamab and Lazertinib Combination Therapy Versus Single Agent Osimertinib Versus Lazertinib as First-Line Treatment in Patients with EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer – MARIPOSAAmivantamab (JNJ-61186372)Phase 3Open
Lung and ThoraxNSCLCMK7684A-0022020-004034-38A Phase 2, Multi-center, Randomized Study to Compare the Efficacy and Safety of MK-7684A Or MK-7684A Plus Docetaxel Versus Docetaxel Monotherapy in the Treatment of Participants With Metastatic Non-small Cell Lung Cancer With Progressive Disease After Treatment With A Platinum Doublet Chemotherapy and Immunotherapy MK-7684APhase 2Open
Lung and ThoraxNSCLCCodeBreaK 1002018-001400-11A Phase 1/2, Open-label Study Evaluating the Safety, Tolerability,Pharmacokinetics, Pharmacodynamics, and Efficacy of AMG 510 Monotherapy in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation and AMG 510 Combination Therapy in Subjects With Advanced NSCLC With KRAS p.G12C Mutation (CodeBreaK 100)AMG 510Phase 2Open
All tumorsAll tumorsPrecision 2 - Afatinib2016-003411-34 Precision 2: an open explorative phase II, open label study of afatinib in the treatment of advanced cancer carrying an EGFR, a HER2 or a HER3 mutation followed by the addition of paclitaxel to afatinib at disease progression.AfatinibPhase 2Open
All tumorsAll tumorsPrecision 2 – Olaparib 2018-002966-37 Efficacy of Olaparib in advanced cancers occurring in patients with germline mutations or somatic tumor mutations in homologous recombination genes. SAUF SEIN, OVAIRE, PROSTATE, ATM gene
Olaparib Phase 2Open
All tumorsAll tumors DF1001-001 2019-004706-10A phase I/II, first-in-human, multi-part, open-label, multiple ascending dose study to investigate the safety, tolerability, pharmacokinetics, biological, and clinical activity of DF1001 in patients with locally advanced or metastatic solid tumors, and expansion in selected indicationsDF1001Phase 2Open
All tumorsAll tumorsPrecision 1 The Belgian Molecular Profiling Program of Metastatic Cancer for Clinical Decision and Treatment Assignment
“PRECISION 1”
Prospective-Collection d'échantillonsOpen
All tumorsAll tumorsGeNeoA study to examine the value of broad agnostic NGS panel testing versus reimbursed organ-directed NGS: a Belgian Precision study of the BSMO in collaboration with the Cancer Centre.
Prospective-Collection d'échantillonsOpen
All tumorsAll tumorsTAPISTRY2020-001847-16Phase II, global, multicenter, open-label, multi-cohort study designed to evaluate the safety and efficacy of targeted therapies or immunotherapy as single agents or in rational, specified combinations in patients with unresectable, locally advanced or metastatic solid tumors determined to harbor specific oncogenic genomic alterations or who are TMB-high as identified by an next-generation-sequencing (NGS) assayPhase 2Open
All tumorsAll tumorsBALLETTA study to examine the clinical value of comprehensive genomic profiling performed by Belgian NGS laboratories: a Belgian Precision study of the BSMO in collaboration with the Cancer Centre - Belgian Approach for Local Laboratory Extensive Tumor Testing (BALLETT)Prospective-Collection d'échantillonsOpen
All tumorsAll tumorsSGNTUC-019A phase 2 basket study of Tucatinib in combination with Trastuzumab in subjects with previously treated, locally advanced unresectable or metastatic solid tumors driven by HER2 alterationsTucatinibPhase 2Open
All tumorsAll tumorsBrainStorm programA Brain metastases research Platform to tackle the challenge of CNS metastases in solid tumoursProspective-Collection d'échantillonsOpen
Lung and ThoraxSCLCMK7339-013 2019-003616-31A Randomized, Double-blind, Placebo-controlled Phase 3 Study of Pembrolizumab (MK-3475) in Combination with Concurrent Chemoradiation Therapy Followed by Pembrolizumab with or without Olaparib (MK-7339), Compared to Concurrent Chemoradiation Therapy Alone in Participants with Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC) Pembrolizumab (MK-3475)Phase 3Near future
Lung and ThoraxNSCLC849-012 (Krystal program)A randomized Phase 3 study of MRTX849 versus Docetaxel in Patients with Previously Treated Non-Small Cell Lung Cancer with KRAS G12C MutationMRTX849 (KRAS G12C inhibitor)Phase 3Near future
Lung and ThoraxSCLCCA001-050A Randomized, Open-label Phase 2 Clinical Trial of BMS-986012 in Combination with Carboplatin, Etoposide, and Nivolumab as First-line Therapy in Extensive-stage Small Cell Lung CancerBMS-986012Phase 2Near future

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